MOTS-C
A 16-amino-acid mitochondrial-derived peptide encoded by 12S rRNA, central to metabolic homeostasis.
How it works
Activates AMPK, regulates folate-methionine cycle, improves glucose disposal and exercise capacity.
Reported benefits
- Improved insulin sensitivity and exercise capacity in animal models
- Reduced age-related decline in skeletal-muscle function in mice
- Investigated for metabolic syndrome
Dosage & administration
Research range: 5-10 mg subcutaneously 2-3x weekly.
Dosing information is summarised from published clinical and pre-clinical literature for research purposes only and does not constitute medical advice.
Clinical & pre-clinical evidence
MOTS-c regulates metabolic homeostasis
Cell Metabolism · 2015
Reversed insulin resistance and diet-induced obesity in mice.
Safety & warnings
- Limited human safety data
- Use under research supervision
For research use. Consult a licensed clinician before any human application. Not for use in pregnancy, lactation, or active malignancy without specialist supervision.
Available presentations
10 mg
MS10
Box of 10 · $204
Single vial · $408
40 mg
MS40
Box of 10 · $675
Single vial · $1,350
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