Kisspeptin-10
A 10-amino-acid fragment of kisspeptin, the master upstream regulator of GnRH and reproductive endocrinology.
How it works
Activates KISS1R on hypothalamic GnRH neurons, restoring physiologic LH and FSH pulsatility.
Reported benefits
- Restores LH pulsatility in hypothalamic amenorrhea (Imperial College trials)
- Investigated as a fertility induction tool with low OHSS risk
- Improved sexual-arousal brain signalling in healthy men (fMRI)
Dosage & administration
Research range: 1-9 mcg/kg subcutaneous bolus or continuous infusion in clinical studies.
Dosing information is summarised from published clinical and pre-clinical literature for research purposes only and does not constitute medical advice.
Clinical & pre-clinical evidence
Kisspeptin restores LH pulsatility in hypothalamic amenorrhea
Journal of Clinical Investigation · 2014
Single bolus restored LH pulsatility in affected women.
Safety & warnings
- Generally well tolerated short term
- Endocrine effects — use under supervision
For research use. Consult a licensed clinician before any human application. Not for use in pregnancy, lactation, or active malignancy without specialist supervision.
Available presentations
5 mg
KS5
Box of 10 · $180
Single vial · $360
10 mg
KS10
Box of 10 · $351
Single vial · $702
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