AICAR
An AMPK-activating nucleoside analogue investigated for endurance and metabolic effects.
How it works
Mimics AMP, activating AMPK and downstream PGC-1α, promoting mitochondrial biogenesis and fatty-acid oxidation.
Reported benefits
- Increased endurance capacity in sedentary mice
- Improved glucose handling
- Potential cardioprotective effects
Dosage & administration
Research only; banned by WADA. Pre-clinical mouse dosing ~500 mg/kg daily IP.
Dosing information is summarised from published clinical and pre-clinical literature for research purposes only and does not constitute medical advice.
Clinical & pre-clinical evidence
AMPK agonists make mice 'exercise endurance' phenotype
Cell · 2008
AICAR alone improved running endurance ~44% in sedentary mice.
Safety & warnings
- WADA-prohibited in competition
- Long-term human safety unknown
For research use. Consult a licensed clinician before any human application. Not for use in pregnancy, lactation, or active malignancy without specialist supervision.
Available presentations
50 mg
AR50
Box of 10 · $180
Single vial · $360
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